What is the MPV blood test for
MPV (mean platelet volume)
MPV value for the mean platelet volume
The MPV value acts as a measure of the mean volume of platelets in the body. This measured value provides information about complications in the form and number of platelets in the blood. MPV stands for the English term "Mean platelet volume". In German, the abbreviation MPV is used more and more (mean platelet volume) by.
The average platelet volume measured depends on the age of the platelets. Few platelets indicate a high MPV. If there is an increased reading in the small blood count, doctors warn that the blood vessels are blocked. A heart attack results as a result. The increased MPV value is mainly caused by bacterial infections and diabetes. On the other hand, chronic kidney damage and AIDS cause small readings.
Measuring the MPV
As a laboratory parameter, the unit of the mean volume of the platelets is "emto volume per platelet size". Doctors determine the exact values of the platelet count in a blood count.
Since the MPV value averages the volume of the platelets, it depends on their lifespan. The maturation of the megakaryocytes also plays a key role in determining the value. The measuring process is based on a count of the particles. This is done according to the Coulter principle or flow cytometry.
Doctors use hematology equipment to get an accurate blood count. Certain signals provide information about the volume of the individual particles. All hematology devices measure the average volume of blood platelets. As a rule, this value is not on the medical report. Finding the average platelet volume is considered a prophylactic examination. The focus here is on controlling the number and shape of blood platelets. If the value is outside the norm, the person concerned suffers from a disorder in the organism.
To the EDTA blood is suitable for determining the MPV value. This is the blood that contains the hexagonal complexing agent EDTA. This contains a large number of platelets. Four milliliters of sufficiently mixed blood are sufficient for an exact result. The platelets swell after long periods of storage in the EDTA blood. In the best case scenario, the measurement is therefore carried out in a period of three hours. On average, the mean volume of platelets is seven to twelve.
What did the MPV say?
The MPV value provides information about a possible thrombocytopenia. The average volume determines a dependency on an increased consumption of blood platelets.
Infections or hemophilia are the cause here. The mean platelet count also addresses the reduction in platelet formation. In any case, the platelets shrink as they age. Accordingly, the heterogeneous megakaryocytes in the bone marrow influence the measured value. These interact with the platelets in the body.
In the peripheral blood, low platelet counts lead to high MPV. Doctors warn against a re-infarction in the event of such a finding. This usually follows a myocardial infarction. With an increased reading, macrotiplatelets indicate diseases such as the May-Hegglin anomaly.
Some platelet aggregates break down using a volume distribution curve. A small volume average indicates a disruption in platelet formation.
What does a high MPV mean?
The increased MPV value is due to the following reasons:
- Heart attack
- Diabetes mellitus
- hereditary macrothrombocytosis
- chronic hypoxia
Hereditary diseases also lead to a high MPV. Such disorders are represented by the Bernard-Soulier syndrome or the Fechtner syndrome. Furthermore, the Sebastian syndrome and the May-Hegglin anomaly, which causes macro-platelets, are present.
What is the result of the low MPV?
A low average platelet volume is due to high platelet consumption. Diseases that lead to this syndrome are called
- Bone marrow aplasia,
- reactive thrombocytosis,
- Renal failure,
- and hypothyroidism.
If the reading is lowered, it may be due to myeloproliferative diseases. Chemotherapy ensures a high consumption of platelets. Here, too, there is a low average volume. Some people also suffer from a hereditary disease. This is called Wiskott-Aldrich syndrome.
Basically, the value of the mean platelet volume is used to control the blood platelets. The focus is on the shape and number of platelets. Changed values indicate an increased consumption or an excessive formation of the blood platelets.
editing: Anna Nilsson
As a medical editor, he has been providing information on medical issues in this project since 2012. This article corresponds to the current state of medical knowledge and current medical specialist literature.
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