How is tetramethylorthosilicate TMOS synthesized

Prevention of Candida Infections on Titanium Based Biomaterials

Prosthetic joint infections are one of the most dangerous and devastating complications after total joint replacement, with significant implications for patient health and high public health costs. Fungal infections are of concern to the orthopedic community because of their recently increasing incidence and resistance to antifungal drugs.

Nowadays these infections are prevented by the prophylactic administration of antifungal drugs. In the current research, scientists propose an alternative to this approach by achieving a local prevention of infections through plaque deposited on the implants and contaminated with antifungal agents. In this way, new biodegradable coatings with the incorporation of antifungal agents for the local release of the drug were synthesized. The coatings were produced using sol-gel technology based on 3- (trimethoxysilyl) propyl methacrylate (MAPTMS) and tetramethyl orthosilicate (TMOS). Two different fungicides (fluconazole and anidulafungin) were applied separately in different concentrations. The coatings were applied to powder-metallurgical titanium substrates (TiPM) using an immersion process.

Alternative for preventing prosthetic joint infections

The study showed that the release of the antifungal agents physically entrapped in the polysiloxane network is proportional to the degradation of the coatings. In addition, the degradation kinetics in fluconazole-containing coatings differed from those loaded with anidulafungin and depended on the selected precursors and their molar ratio as well as on the molecular weight and the concentration of the active ingredient. Synthetic coatings, which are loaded with anidulafungin, are presented as an alternative to prevent prosthetic joint infections, since the in-vitro tests carried out showed their non-cytotoxicity with simultaneous antifungal activity.

The study was published in Progress in Organic Coatings, Volume 146, September 2020.

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