What are the chemical properties of digoxin

Digoxin (DIGOX)

Digoxin belongs to the group of cardiac glycosides. These drugs are used to treat heart failure (heart failure) and certain types of irregular heartbeat.

Cardiac muscle weakness is a disease in which the heart is no longer able to provide a delivery performance that meets the requirements. The physical symptoms of heart failure result from this, so that there is virtually a backlog of blood in front of the heart. The heart is just too weak to perform its pumping task. This blood backlog leads to:

  • Swelling in both legs (leg edema),
  • Fluid build-up in the lungs (pulmonary edema - "water in the lungs"),
  • Shortness of breath,
  • Shortness of breath etc.

The drug digoxin is obtained from the leaves of the woolly thimble (digitalis lanata). Digoxin has a narrow therapeutic range - i.e. the concentration range between underdosing (ineffectiveness of the drug) and overdosing (toxic side effects of the drug) is narrow.

In addition to the narrow therapeutic range, digoxin also has a long half-life of one to two days. This means that it takes an average of one to two days for the blood level of this drug to halve after the last dose.

Because of these special properties of digoxin, the prescription must be followed closely with this drug. Regular “therapeutic drug monitoring” (TDM; determination of the drug level in the blood) is to be carried out to control the therapy.